Rolac 10mg Tablet (56pcs Box)

Uses of Rolac 10mg Tablet

• Moderate to Severe Pain
• Postoperative Pain Relief

How does Rolac 10mg Tablet work?

Rolac 10mg Tablet works by blocking the effects of prostaglandins, which are substances produced by the body in response to injury or inflammation. Prostaglandins are responsible for causing pain, swelling, and inflammation at the site of injury. By inhibiting the production of prostaglandins, ketorolac reduces pain and inflammation.

Additionally, ketorolac also inhibits the transmission of pain signals between the nerve endings and the brain. This further contributes to its analgesic effects, as it helps to reduce the perception of pain.

By blocking prostaglandins and inhibiting pain signals, the ketorolac tablet provides relief from moderate to severe pain, such as post-operative pain or musculoskeletal pain.

Side Effects of Rolac 10mg Tablet

• Swelling of face, lips, eyelids, tongue, hands and feet
• Unexpected weight gain
• Skin rash
• Mouth ulcers
• Abdominal pain
• Decreased urine output
• Yellow-colored eyes or skin
• Diarrhea
• Drowsiness
• Headache

Quick Suggestions:

• Take it with food or milk to prevent stomach upset.
• Follow the prescribed dose and duration recommended by your doctor. Long-term use can have serious complications like stomach bleeding and kidney problems.
• Be cautious of dizziness, drowsiness, or visual disturbances. Avoid activities that require concentration, such as driving, if affected.
• Do not consume alcohol while taking Rolac 10mg Tablet as it can increase drowsiness and the risk of stomach issues.
• Inform your doctor if you have a history of heart disease or stroke.
• If using the medicine for long-term treatment, your doctor may monitor kidney and liver function, as well as blood components.
• Regular exercises, such as jogging and walking, can help stretch muscles and prevent spasms, tears, and sprains.
• Consider massages for additional relief.
• Avoid extreme temperatures (freezing or hot) and opt for loose-fitting clothing instead of tight garments.
• Get enough rest and sleep.
• Change your position every two hours to prevent pressure sores.
• Apply ice or heat packs for 15-20 minutes to alleviate muscle spasms.
• Stay hydrated by drinking plenty of water.

Indication of Rolac 10mg Tablet

Rolac 10mg Tablet is primarily used for the short-term management of sudden moderate to severe pain, typically after surgical procedures. It is also effective in providing relief from musculoskeletal pain, which includes pain in the muscles, bones, joints, ligaments, or tendons. Rolac 10mg Tablet can help alleviate pain in conditions such as fractures, sprains, strains, and other musculoskeletal injuries. However, it's important to note that ketorolac should be used for a short duration (up to five days) due to its potential side effects on the gastrointestinal system and kidneys.

Pharmacology

Ketorolac tromethamine, classified as a non-steroidal anti-inflammatory drug (NSAID), is a powerful analgesic. Its main mechanism of action involves the inhibition of the cyclooxygenase enzyme system, which is responsible for the production of prostaglandins. By inhibiting this enzyme system, ketorolac tromethamine reduces the production of prostaglandins, which are involved in pain and inflammation signaling pathways.

It's important to note that ketorolac tromethamine primarily functions as an analgesic at therapeutic doses, meaning it primarily provides pain relief rather than exerting a significant anti-inflammatory effect. This distinguishes it from other NSAIDs that are commonly used for their anti-inflammatory properties.

Dosage & Administration of Rolac 10mg Tablet

Adult Dose:

Oral: For short-term management of moderately severe acute pain that requires opioid-level analgesia, the initial dose is 20 mg taken once after IV or IM therapy. After the initial dose, a maintenance dose of 10 mg can be taken every 4 to 6 hours, not exceeding a total daily dose of 40 mg.

IV: A single dose of 30 mg can be administered or 30 mg every 6 hours, with a maximum daily dose of 120 mg.

IM: A single dose of 60 mg can be administered or 30 mg every 6 hours, with a maximum daily dose of 120 mg.

Elderly: The dosing for elderly patients is reduced compared to adults. For IV and IM administration, the initial dose is 15 mg as a single dose or 15 mg every 6 hours, with a maximum daily dose of 60 mg. For oral administration, the initial dose is 10 mg taken once after IV or IM therapy, followed by a maintenance dose of 10 mg every 4 to 6 hours, not exceeding a total daily dose of 40 mg.

Child Dose:

Children aged 2 to 16 years can receive a single dose of 0.5 mg/kg IV/IM once, not exceeding 15 mg. For multiple doses, the recommended regimen is 0.5 mg/kg IV/IM every 6 hours, not exceeding a duration of 5 days.

Renal Dose:

In patients with severe renal impairment, Ketorol should not be used. For patients with moderate renal impairment (moderately elevated serum creatinine), the dosage should be reduced to 50% of the recommended dosage, not exceeding a total daily dose of 60 mg for IM/IV administration.

It's important to note that this is a paraphrased summary and should not replace the specific instructions and guidance provided by a healthcare professional.

Interaction

Rolac 10mg Tablet may interact with certain medications such as blood thinners (warfarin, heparin), antipsychotic agents (lithium), pain killers (aspirin), uricosuric medications (probenecid), and anti-progestational steroids (mifepristone). It is important to inform your doctor about any pre-existing medical conditions, including stomach ulcers or perforation, bleeding problems, heart problems, blood circulation problems, asthma, fluid retention, thrombosis, porphyria, anemia, high blood pressure, and kidney or liver problems.

Contraindications

Patients who are hypersensitive to ketorolac or other NSAIDs should avoid using it. It should not be given to youngsters under the age of sixteen. It's also not a good idea to use it as a pre-surgery analgesic.

Pregnancy & Lactation

Ketorolac tromethamine, the active ingredient in Rolac 10, is classified by the US FDA as Pregnancy Category C. This means that it may not be safe for use during pregnancy and lactation unless the potential benefits to the mother outweigh the potential risks to the fetus or breastfeeding infant. It is recommended to consult with a healthcare professional before using this medication during pregnancy or while breastfeeding to assess the individual risks and benefits in your specific situation.

Precautions & Warnings

Do not use Rolac 10mg Tablet if:

• You are allergic to any of its ingredients.
• You have a history of asthma, severe heart problems, stomach ulcer or perforation, bleeding problems, recent bypass surgery, heart attack, blood circulation issues, or inflammation of the intestines.
• Taking Rolac 10mg Tablet can increase the risk of a fatal heart attack or stroke.
• If you are pregnant or breastfeeding, avoid using Rolac 10mg Tablet.
• Inform your doctor if you have or had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver or kidney problems.
• Rolac 10mg Tablet is recommended for children below 16 years as the safety and effectiveness were not established.
• Use caution while driving, as Rolac 10mg Tablet may cause dizziness.
• Rolac 10mg Tablet is not recommended for children below 16 years old, as its safety and effectiveness have not been established.
• Stop taking Rolac 10mg Tablet and consult your doctor immediately if you experience stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools.
• Do not combine Rolac 10mg Tablet with other NSAIDs for pain relief unless prescribed by your doctor.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.